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Volume 103, Issue 3
October 2019
Research Articles| August 28 2019
Subject Area: Further Areas
SangHyun Yoo;
SangHyun Yoo
Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea
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Hwanik Kim;
Hwanik Kim
Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea
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Cheol Kwak;
Cheol Kwak
Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea
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HyeonHoe Kim;
HyeonHoe Kim
Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea
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JaeHyun Jung;
JaeHyun Jung
Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea
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JaHyeon Ku
Department of Urology, Seoul National University Hospital, Seoul, Republic of Korea
randyku@hanmail.net
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randyku@hanmail.net
Urol Int (2019) 103 (3): 291–296.
Article history
Received:
March 11 2019
Accepted:
August 12 2019
Published Online:
August 28 2019
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Citation
SangHyun Yoo, Hwanik Kim, Cheol Kwak, HyeonHoe Kim, JaeHyun Jung, JaHyeon Ku; Late Recurrence of Bladder Cancer following Radical Cystectomy: Characteristics and Outcomes. Urol Int 16 October 2019; 103 (3): 291–296. https://doi.org/10.1159/000502656
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Abstract
Purpose: There are only a few studies on characteristics and outcomes of late recurrence (LR) of urothelial carcinoma of bladder (UCB) after radical cystectomy (RC). The objective of this study was to assess characteristics and oncological outcomes of such LR that developed 5 years after RC. Materials and Methods: We retrospectively reviewed 570 patients who underwent RC and bilateral regional lymphadenectomy for UCB at our institution. Comparisons of post-recurrence disease-specific survival (DSS) according to the timing of recurrence and the site of recurrence were performed using Kaplan-Meier survival curves and log-rank test. Cox regression model was fitted to assess factors for post-recurrence DSS. Results: Disease recurrence occurred in 214 (37.5%) patients, including 20 (9.3%) who had LRs. Median time from RC to recurrence was 13.0 (interquartile range 6.0–32.0) months. There were no significant differences in clinicopathological factors between early- and late-recurrence groups. Post-recurrence 5-year DSS was not significantly different (21.6 vs. 14.1%, p = 0.344) between early- and late-recurrence groups. However, it was worse in the nonurothelial recurrence group compared to that in the urothelial recurrence group (14.0 vs. 19.4%, p = 0.056). Older age (HR 1.03, 95% CI 1.01–1.05, p = 0.001), nonorgan-confined disease at RC (HR 1.73, 95% CI 1.15–2.61, p = 0.008), and lymph node invasion (HR 1.58, 95% CI 1.01–2.45, p = 0.043) were significant predictors for post-recurrence 5-year DSS. Conclusions: LR after RC with lymphadenectomy is not common. However, it cannot be overlooked. LR had similar characteristics to early recurrence. Interestingly, the time to recurrence did not affect post-recurrence survival.
Keywords:
Urinary bladder, Carcinoma, Late recurrence, Survival
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© 2019 S. Karger AG, Basel
2019
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